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Najnowsze postępy w bioanalitycznych metodach wykrywania biomarkerów
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ISBN10: 6200749175
ISBN13: 9786200749178
Publisher: Wydawnictwo Nasza Wiedza
Published: Jul 23 2025
Pages: 92
Weight: 0.30
Height: 0.22 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786200749178
Publisher: Wydawnictwo Nasza Wiedza
Published: Jul 23 2025
Pages: 92
Weight: 0.30
Height: 0.22 Width: 6.00 Depth: 9.00
Language: Polish
Zakażenia schistosomami mają poważne konsekwencje dla rozwoju spoleczno-gospodarczego wielu krajów tropikalnych. Te wyniszczające i przewlekle choroby występują endemicznie w ponad 70 krajach, ale narzędzia diagnostyczne są ograniczone i konieczne są nowe testy, aby ograniczyc zachorowalnośc i śmiertelnośc. Opracowanie takich testów może zostac ulatwione dzięki identyfikacji biomarkerów specyficznych dla danej choroby, które są dodatnie we wczesnej fazie zakażenia, pozwalają odróżnic zakażenie ostre od przewleklego i mogą slużyc do potwierdzenia wyleczenia. Niniejsza praca ma dwa glówne cele: (a) identyfikację wzorców proteomicznych specyficznych dla poszczególnych stadiów wczesnego (3 tygodnie), ostrego (6 tygodni) i przewleklego (12 tygodni) zakażenia Schistosoma mansoni w modelu mysim; (b) profilowanie surowicy osób zakażonych S. mansoni lub S. haematobium i porównanie tych wzorców z profilem bialkowym surowicy zdrowych osób. Aby osiągnąc te cele, przeprowadzono analizy proteomiczne surowicy myszy i ludzi przy użyciu kilku różnych metod spektrometrii masowej (MS).
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