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The Kinetochore: From Molecular Discoveries to Cancer Therapy
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ISBN13: 9781441923981
Publisher: Springer
Published: Dec 24 2010
Pages: 516
Weight: 1.60
Height: 1.50 Width: 6.10 Depth: 9.00
Language: English
Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. The Kinetochore: from Molecular Discoveries to Cancer Therapy presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and model eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.
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