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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Mechanism of Bone Destruction

Mechanism of Bone Destruction

Gupta, Shivani
Agarwal, Prerna
Agarwal, Ashutosh

Paperback

Medical Reference

ISBN10: 620844523X
ISBN13: 9786208445232
Publisher: LAP Lambert Academic Publishing
Published: Jun 6 2025
Pages: 88
Weight: 0.28
Height: 0.21 Width: 6.00 Depth: 9.00
Language: English
Bone destruction is central to conditions like osteoporosis, rheumatoid arthritis, and cancers with bone metastases. It results from an imbalance between bone resorption by osteoclasts and formation by osteoblasts. Osteoclast activity is regulated by the RANK/RANKL/OPG axis, where an increased RANKL/OPG ratio promotes osteoclastogenesis. Inflammatory cytokines (e.g., TNF-α, IL-1, IL-6) enhance RANKL expression and osteoclast survival. In cancer, tumor-derived factors like PTHrP and prostaglandins further drive RANKL-mediated bone loss. Bone resorption releases growth factors such as TGF-β, fueling tumor growth and perpetuating degradation. Enzymes like MMPs and cathepsin K degrade bone matrix, while hypoxia and mechanical stress also contribute. Understanding these mechanisms supports treatments like bisphosphonates, RANKL inhibitors (e.g., denosumab), and anti-cytokine therapies, which effectively reduce bone loss.

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