Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology

Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology

Mumberg, Dominik
Keun, Kector
Kroemer, Guido

Hardcover

Series: Ernst Schering Foundation Symposium Proceedings, Book 2007

Medical ReferenceAnatomy & PhysiologyChemistry

ISBN10: 3540794778
ISBN13: 9783540794776
Publisher: Springer
Published: Aug 20 2008
Pages: 265
Weight: 1.05
Height: 0.60 Width: 5.90 Depth: 8.40
Language: English

In 1920s, Otto Warburg described the phenomenon of 'aerobic glycolysis', the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg's hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).

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