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Tef1 jest bialkiem wieloczynnikowym Candida albicans
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ISBN10: 6203573213
ISBN13: 9786203573213
Publisher: Wydawnictwo Nasza Wiedza
Published: Jun 25 2025
Pages: 112
Weight: 0.35
Height: 0.27 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786203573213
Publisher: Wydawnictwo Nasza Wiedza
Published: Jun 25 2025
Pages: 112
Weight: 0.35
Height: 0.27 Width: 6.00 Depth: 9.00
Language: Polish
W niniejszej pracy po raz pierwszy wykazano na poziomie komórkowym wplyw pojedynczego bialka powierzchniowego na unikanie komplementu i ukladu odpornościowego przez Candida albicans. Tef1 (Translation Elongation Factor 1) jest bialkiem moonlightingowym C. albicans. Jest ono ekspresjonowane na powierzchni komórki, wydzielane, a ponadto zlokalizowane w cytoplazmie jako czynnik translacyjny. Tef1 dziala zarówno jako CRASP (bialko powierzchniowe regulujące dopelniacz) bezpośrednio w miejscu ekspresji, jak i jako bialko wydzielane z dala od powierzchni komórki grzyba. Tef1 wiąże się z komórkami i skladnikami wrodzonego ukladu odpornościowego i wplywa na uklad odpornościowy adaptacyjny, w szczególności na komórki B. Ogólnie rzecz biorąc, Tef1 jest wieloczynnikowym bialkiem unikającym odpowiedzi immunologicznej C. albicans. Jego charakterystyka moonlighting jako bialka powierzchniowego i wydzielanego pozwala Tef1 modulowac zarówno wrodzoną (kaskada dopelniacza), jak i adaptacyjną odpowiedź immunologiczną (komórki B). W ten sposób Tef1 na wiele sposobów umożliwia przetrwanie C. albicans w organizmie czlowieka.
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