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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Tef1 is a multifunctional protein of Candida albicans

Tef1 is a multifunctional protein of Candida albicans

Linden, Justus

Paperback

Biology

ISBN10: 6203573221
ISBN13: 9786203573220
Publisher: Our Knowledge Publishing
Published: Jun 25 2025
Pages: 108
Weight: 0.34
Height: 0.26 Width: 6.00 Depth: 9.00
Language: English
This study is the first to demonstrate at the cellular level the contribution of a single surface protein to complement and immune evasion by Candida albicans. Tef1 (translation elongation factor 1) is a moonlighting protein of C. albicans. It is expressed on the cell surface, secreted, and also localized in the cytoplasm as a translation factor. Tef1 acts both as CRASP (complement regulator acquiring surface protein) directly at the site of expression and as a secreted protein away from the fungal cell surface. Tef1 binds to cells and components of the innate immune system and also influences the adaptive immune system, especially B cells. Overall, Tef1 is a multifactorial immune evasion protein of C. albicans. Its moonlighting characteristic as a surface and secreted protein allows Tef1 to modulate both the innate (complement cascade) and adaptive immune responses (B cells). Thus, Tef1 enables the persistence of C. albicans in the human organism in a variety of ways.

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