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Effets à faible dose du bisphénol A sur les cellules primaires et cancéreuses humaines
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ISBN10: 6208358337
ISBN13: 9786208358334
Publisher: Editions Notre Savoir
Published: Dec 6 2024
Pages: 112
Weight: 0.39
Height: 0.27 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786208358334
Publisher: Editions Notre Savoir
Published: Dec 6 2024
Pages: 112
Weight: 0.39
Height: 0.27 Width: 6.00 Depth: 9.00
Language: French
Le bisphénol A (BPA), 2,2-bis(4-hydroxyphényl) propane, est un composé organique et l'un des produits chimiques industriels les plus produits dans le monde. L'exposition humaine au BPA, dans la gamme des faibles doses, est considérée comme un phénomène généralisé, en particulier par ingestion orale. Des études de biosurveillance révèlent la présence de BPA chez la majorité des individus des pays développés. Le BPA est un perturbateur endocrinien bien caractérisé qui peut entraîner des réponses cellulaires très distinctes par le biais de plusieurs voies de signalisation des récepteurs d'oestrogènes fréquemment associées à des spécificités de type cellulaire. Des recherches approfondies sur des lignées cellulaires humaines provenant de tissus sensibles aux hormones sexuelles ont démontré les effets nocifs potentiels de l'exposition au BPA, y compris la cancérogenèse. Cependant, bien que le BPA soit absorbé dans l'intestin et entre dans la circulation sanguine, ses effets sur les cellules des systèmes digestif et vasculaire sont largement inconnus. Il est urgent de répondre aux préoccupations croissantes concernant les effets néfastes potentiels d'une exposition à de faibles doses de BPA et d'évaluer les interactions potentielles dans le contexte de l'évaluation des risques pour la santé humaine.
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