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Fusão vesicular, importação de proteÃnas e clivagem proteolÃtica em eucariotos
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ISBN10: 6209467342
ISBN13: 9786209467349
Publisher: Edicoes Nosso Conhecimento
Published: Jan 12 2026
Pages: 156
Weight: 0.48
Height: 0.36 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209467349
Publisher: Edicoes Nosso Conhecimento
Published: Jan 12 2026
Pages: 156
Weight: 0.48
Height: 0.36 Width: 6.00 Depth: 9.00
Language: Portuguese
Esta publicação apresenta o trabalho de uma dissertação de investigação que contribuiu significativamente para o entendimento atual do transporte intracelular de proteÃnas em duas áreas importantes: fusão vesicular e biogénese de peroxissomas. Esse esforço começou com um estudo das SNAREs, proteÃnas altamente conservadas que formam o mecanismo central de fusão nos sistemas de tráfego secretório e endossomal, descrevendo as primeiras descobertas sobre a regulação de um membro integral desse mecanismo proteico, a sintaxina 5, por meio de sua parceira de ligação proteica rSly1 no retÃculo endoplasmático/Golgi Sec1/Munc18 de mamÃferos. Esta investigação continuou com um exame da importação de proteÃnas da matriz peroxissomal, um modo de transporte de proteÃnas que utiliza dois sinais de direcionamento peroxissomal distintos (PTS1 e 2). Estes estudos focaram-se especificamente na identificação da protease de processamento PTS2. Além disso, foram examinadas duas proteÃnas de Arabidopsis thaliana que possuem sinais PTS1 e PTS2 putativos. Assim, utilizando técnicas de biologia celular e molecular, esta investigação expandiu a área do transporte intracelular de proteÃnas.
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