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Fusione vescicolare, importazione proteica e scissione proteolitica negli eucarioti
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ISBN10: 6209464785
ISBN13: 9786209464782
Publisher: Edizioni Sapienza
Published: Jan 12 2026
Pages: 156
Weight: 0.48
Height: 0.36 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786209464782
Publisher: Edizioni Sapienza
Published: Jan 12 2026
Pages: 156
Weight: 0.48
Height: 0.36 Width: 6.00 Depth: 9.00
Language: Italian
Questa pubblicazione presenta il lavoro di una tesi di ricerca che ha fornito importanti contributi all'attuale comprensione del traffico proteico intracellulare in due aree significative: la fusione vescicolare e la biogenesi dei perossisomi. Questo lavoro è iniziato con uno studio sulle SNARE, proteine altamente conservate che costituiscono il meccanismo di fusione centrale nei sistemi di traffico secretorio ed endosomiale, descrivendo i primi risultati relativi alla regolazione di un membro integrante di questo meccanismo proteico, la sintaxina 5, attraverso il suo partner di legame proteico rSly1 nel reticolo endoplasmatico/Golgi Sec1/Munc18 dei mammiferi. Questa ricerca è proseguita con l'esame dell'importazione delle proteine della matrice dei perossisomi, una modalità di trasporto delle proteine che utilizza due distinti segnali di targeting perossisomiale (PTS1 e 2). Questi studi si sono concentrati in particolare sull'identificazione della proteasi di elaborazione PTS2. Inoltre, sono state esaminate due proteine di Arabidopsis thaliana che possiedono entrambi i segnali PTS1 e PTS2. Pertanto, utilizzando tecniche di biologia cellulare e molecolare, questa ricerca ha ampliato l'area del traffico proteico intracellulare.
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