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Vesikelfusion, Proteinimport und proteolytische Spaltung in Eukaryoten
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ISBN10: 620945710X
ISBN13: 9786209457104
Publisher: Verlag Unser Wissen
Published: Jan 12 2026
Pages: 156
Weight: 0.48
Height: 0.36 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786209457104
Publisher: Verlag Unser Wissen
Published: Jan 12 2026
Pages: 156
Weight: 0.48
Height: 0.36 Width: 6.00 Depth: 9.00
Language: German
Diese Veröffentlichung präsentiert die Arbeit einer Forschungsdissertation, die wichtige Beiträge zum aktuellen Verständnis des intrazellulären Proteintransports in zwei wichtigen Bereichen geleistet hat: Vesikelfusion und Peroxisombiogenese. Diese Arbeit begann mit einer Untersuchung von SNAREs, hochkonservierten Proteinen, die den Kern des Fusionsmechanismus innerhalb sekretorischer und endosomaler Transportsysteme bilden, und beschreibt frühe Erkenntnisse über die Regulation eines integralen Bestandteils dieses Proteinmechanismus, Syntaxin 5, durch seinen Bindungspartner rSly1 im endoplasmatischen Retikulum/Golgi Sec1/Munc18 von Säugetieren. Diese Forschung wurde mit einer Untersuchung des Importes von Peroxisomenmatrixproteinen fortgesetzt, einer Art des Proteintransports, die zwei unterschiedliche Peroxisomen-Targeting-Signale (PTS1 und 2) nutzt. Diese Studien konzentrierten sich speziell auf die Identifizierung der PTS2-verarbeitenden Protease. Darüber hinaus wurden zwei Arabidopsis thaliana-Proteine untersucht, die sowohl mutma liche PTS1- als auch PTS2-Signale besitzen. Somit hat diese Forschung mithilfe zellulärer und molekularbiologischer Techniken den Bereich des intrazellulären Proteintransports erweitert.
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