Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Protein Instability at Interfaces During Drug Product Development: Fundamental Understanding, Evaluation, and Mitigation

Protein Instability at Interfaces During Drug Product Development: Fundamental Understanding, Evaluation, and Mitigation

Li, Jinjiang
Krause, Mary E.
Tu, Raymond

Paperback

Series: Aaps Advances in the Pharmaceutical Sciences, Book 43

Medical ReferenceChemistry

ISBN10: 3030571793
ISBN13: 9783030571795
Publisher: Springer Nature
Published: Feb 13 2022
Pages: 338
Weight: 1.07
Height: 0.72 Width: 6.14 Depth: 9.21
Language: English

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in thesurface science, pharmaceutical, and medicinal chemistry areas.

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