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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Cytochrome P450: In Vitro Methods and Protocols

Cytochrome P450: In Vitro Methods and Protocols

Yan, Zhengyin
Caldwell, Gary W.

Paperback

Series: Methods in Pharmacology and Toxicology

Medical ReferenceChemistry

ISBN10: 1071615440
ISBN13: 9781071615447
Publisher: Humana Pr
Published: Jul 10 2022
Pages: 379
Weight: 1.49
Height: 0.81 Width: 7.00 Depth: 10.00
Language: English
This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the Methods in Pharmacology and Toxicology series, chapters include helpful background information on the in vitro assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading.

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