Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Thrombotic Microangiopathies in Pediatrics

Thrombotic Microangiopathies in Pediatrics

Bayene, Maalej
Manel, Weli

Paperback

Medical Reference

ISBN10: 6206814777
ISBN13: 9786206814771
Publisher: Our Knowledge Publishing
Published: Apr 30 2025
Pages: 60
Weight: 0.21
Height: 0.14 Width: 6.00 Depth: 9.00
Language: English
Thrombotic microangiopathies (TMAs) are pathologies characterized by the combination of mechanical microangiopathic hemolytic anemia, thrombocytopenia and target-organ damage of varying severity requiring urgent management. In children, the most frequent etiology of TMAs is Shigatoxin-producing Escherichia coli (STEC) hemolytic uremic syndrome (HUS), formerly known as typical HUS. Other HUS are called atypical HUS, and include HUS secondary to Streptococcus Pneumoniae infection, HUS secondary to Haemophilus Influenzae infection, and dysregulation of the alternative complement pathway. Other etiologies include thrombopathic thrombocytopenic purpura (TTP) due to ADAMTS 13 deficiency, and other less frequent causes such as drug-induced, post-transplant, autoimmune and genetic. The course of the disease can be marked by renal and extra-renal complications, which can be life-threatening. Management is based on correction of hydroelectrolytic disorders, extra-renal purification, plasmapheresis and monoclonal antibodies.

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