Examining Glucagon-Like Peptide-1 Receptor (Glp-1r) Agonists for Central Nervous System Disorders: Proceedings of a Workshop

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ISBN10: 030973505X
ISBN13: 9780309735056
Publisher: National Academies Press
Published: Nov 27 2025
Pages: 118
Weight: 0.40
Height: 0.40 Width: 5.99 Depth: 8.91
Language: English

Glucagon-like peptide-1 receptor (GLP-1R) agonists, originally developed for type 2 diabetes patients and popularized by their ability to rapidly reduce body weight in patients with obesity, have recently received a lot of national attention. Repurposing GLP-1R agonists to treat some central nervous disorders is promising, but comparatively understudied. At a September 2024 workshop, the National Academies Forum on Neuroscience and Nervous System Disorders reviewed the current knowledge and research gaps about the mechanisms of action of GLP-1R agonists in the brain, and the evidence of their clinical efficacy for eating disorders, neurodegenerative diseases, substance use disorders, and pain.

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