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Gènes et cancer de la bouche
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ISBN10: 6208614880
ISBN13: 9786208614881
Publisher: Editions Notre Savoir
Published: Jan 30 2025
Pages: 160
Weight: 0.49
Height: 0.37 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786208614881
Publisher: Editions Notre Savoir
Published: Jan 30 2025
Pages: 160
Weight: 0.49
Height: 0.37 Width: 6.00 Depth: 9.00
Language: French
Dans ce livre, nous étudions les gènes impliqués dans la carcinogenèse buccale et leur utilisation en thérapie génique. La carcinogenèse est un processus complexe en plusieurs étapes dans lequel les événements génétiques au sein des voies de transduction du signal régissant la physiologie cellulaire normale sont modifiés quantitativement. La base génétique du cancer est désormais bien établie. Dans des conditions normales, ces voies excitatrices et inhibitrices étroitement contrôlées régulent la biologie des kératinocytes oraux. Les fonctions cellulaires de base sous ces contrôles comprennent la division cellulaire, la différenciation, la sénescence et l'adhésion. Des facteurs génétiques tels que les oncogènes, les gènes suppresseurs de tumeurs et les gènes régulateurs sont identifiés comme étant impliqués dans la carcinogenèse buccale, ces facteurs de risque étant dépendants et indépendants. Les miARN et Ras Oncogènes sont parmi les plus fréquemment dérégulés génétiquement dans le cancer de la bouche. La thérapie génique contre le cancer représente la majorité des essais cliniques de thérapie génique. Les cibles pour cela comprennent le remplacement des gènes suppresseurs de tumeurs, les gènes suicide pour activer des promédicaments, le transfert de gènes antiangiogéniques basé sur les kines.
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