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Genes e câncer bucal
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ISBN10: 6208614856
ISBN13: 9786208614850
Publisher: Edicoes Nosso Conhecimento
Published: Jan 30 2025
Pages: 152
Weight: 0.47
Height: 0.35 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208614850
Publisher: Edicoes Nosso Conhecimento
Published: Jan 30 2025
Pages: 152
Weight: 0.47
Height: 0.35 Width: 6.00 Depth: 9.00
Language: Portuguese
Neste livro, estudamos os genes envolvidos na carcinogênese oral e seu uso na terapia genética. A carcinogênese é um processo complexo e de várias etapas no qual os eventos genéticos nas vias de transdução de sinal que governam a fisiologia celular normal são quantitativamente alterados. A base genética do câncer está agora bem estabelecida. Em condições normais, estas vias excitatórias e inibitórias rigidamente controladas regulam a biologia dos queratinócitos orais. As funções celulares básicas sob esses controles incluem divisão celular, diferenciação, senescência e adesão. Fatores genéticos como oncogenes, genes supressores de tumor e genes reguladores são identificados como envolvidos na carcinogênese oral com esses fatores de risco de maneira dependente e independente. MiRNAs e Ras Oncogene são um dos mais frequentemente desregulados geneticamente no câncer bucal. A terapia genética para o câncer é responsável pela maioria dos ensaios clÃnicos de terapia genética. Os alvos para isso incluem a substituição de genes supressores de tumor, genes suicidas para ativar pró-drogas, transferência de genes baseados em genes antiangiogênicos.
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