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Geny i rak jamy ustnej
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ISBN10: 6208614902
ISBN13: 9786208614904
Publisher: Wydawnictwo Nasza Wiedza
Published: Jan 30 2025
Pages: 148
Weight: 0.46
Height: 0.34 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786208614904
Publisher: Wydawnictwo Nasza Wiedza
Published: Jan 30 2025
Pages: 148
Weight: 0.46
Height: 0.34 Width: 6.00 Depth: 9.00
Language: Polish
W tej książce badamy geny zaangażowane w karcynogenezę jamy ustnej i ich zastosowanie w terapii genowej. Karcynogeneza to zlożony, wieloetapowy proces, w którym ilościowo zmieniają się zdarzenia genetyczne w obrębie szlaków przekazywania sygnalu regulujących normalną fizjologię komórkową. Genetyczne podloże raka jest obecnie dobrze poznane. W normalnych warunkach te ściśle kontrolowane szlaki pobudzające i hamujące regulują biologię keratynocytów jamy ustnej. Podstawowe funkcje komórkowe podlegające tej kontroli obejmują podzial komórek, różnicowanie, starzenie się i adhezję. Stwierdzono, że czynniki genetyczne, takie jak onkogeny, geny supresorowe nowotworu i geny regulatorowe, biorą udzial w karcynogenezie jamy ustnej, przy czym te czynniki ryzyka są zależne i niezależne. MiRNA i Ras Onkogen jest jednym z najczęściej deregulowanych genetycznie nowotworów jamy ustnej. Terapia genowa raka stanowi większośc badań klinicznych terapii genowej. Cele obejmują wymianę genów supresorowych nowotworu, geny samobójcze aktywujące proleki, transfer genów antyangiogennych w oparciu o kinetykę.
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