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Gene und Mundkrebs
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ISBN10: 6208614864
ISBN13: 9786208614867
Publisher: Verlag Unser Wissen
Published: Jan 30 2025
Pages: 160
Weight: 0.49
Height: 0.37 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786208614867
Publisher: Verlag Unser Wissen
Published: Jan 30 2025
Pages: 160
Weight: 0.49
Height: 0.37 Width: 6.00 Depth: 9.00
Language: German
In diesem Buch untersuchen wir die Gene, die an der oralen Karzinogenese beteiligt sind, und ihre Verwendung in der Gentherapie. Karzinogenese ist ein komplexer, mehrstufiger Prozess, bei dem genetische Ereignisse innerhalb der Signaltransduktionswege, die die normale Zellphysiologie steuern, quantitativ verändert werden. Die genetische Grundlage von Krebs ist mittlerweile gut geklärt. Unter normalen Bedingungen regulieren diese streng kontrollierten erregenden und hemmenden Wege die Biologie der oralen Keratinozyten. Zu den grundlegenden Zellfunktionen unter diesen Kontrollen gehören Zellteilung, Differenzierung, Seneszenz und Adhäsion. Es wurde festgestellt, dass genetische Faktoren wie Onkogene, Tumorsuppressorgene und regulatorische Gene an der oralen Karzinogenese beteiligt sind, wobei diese Risikofaktoren abhängig und unabhängig voneinander sind. MiRNAs und Ras-Onkogene gehören zu den am häufigsten genetisch deregulierten Genen bei Mundkrebs. Die Gentherapie gegen Krebs macht den Gro teil der klinischen Studien zur Gentherapie aus. Zu den Zielen hierfür gehören der Ersatz von Tumorsuppressorgenen, Selbstmordgenen zur Aktivierung von Prodrugs und der kinebasierte Gentransfer antiangiogener Gene.
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