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Regulierung der Fortbewegung durch Theta-Oszillationen im Hippocampus
Paperback
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ISBN10: 6208983479
ISBN13: 9786208983475
Publisher: Verlag Unser Wissen
Published: Jun 20 2025
Pages: 148
Weight: 0.46
Height: 0.34 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786208983475
Publisher: Verlag Unser Wissen
Published: Jun 20 2025
Pages: 148
Weight: 0.46
Height: 0.34 Width: 6.00 Depth: 9.00
Language: German
Theta-Oszillationen im Hippocampus unterstützen die Kodierung der Position eines Tieres während der räumlichen Navigation, und die Theta-Frequenz korreliert mit der Laufgeschwindigkeit. Allerdings blieb lange Zeit unklar, ob Theta-Oszillationen im Hippocampus die Fortbewegung regulieren. Erst seit kurzem können bestimmte Hirnbahnen mit hoher räumlicher und zeitlicher Präzision mithilfe der Optogenetik manipuliert werden. In dieser Studie wurden Theta-Oszillationen im Hippocampus durch optogenetische Stimulation von Schrittmacherzellen im medialen Septum, die mit Theta-Frequenzen zum Hippocampus projizieren, synchronisiert. Die Synchronisation führte zu einer geringeren Variabilität der Theta-Amplitude, was eine langsamere und regelmä igere Laufgeschwindigkeit zur Folge hatte. Die pharmakologische oder optogenetische Hemmung des wichtigsten subkortikalen Outputs des Hippocampus zum lateralen Septum verhinderte die Verhaltenswirkung der Synchronisation. Zusammenfassend liefern die Ergebnisse Hinweise darauf, dass Theta-Oszillationen im Hippocampus die Bewegungsgeschwindigkeit über einen lateralen Septum-Pfad regulieren können.
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