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Regulação da locomoção por oscilações teta do hipocampo
Paperback
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ISBN10: 6208983517
ISBN13: 9786208983512
Publisher: Edicoes Nosso Conhecimento
Published: Jun 20 2025
Pages: 140
Weight: 0.43
Height: 0.33 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208983512
Publisher: Edicoes Nosso Conhecimento
Published: Jun 20 2025
Pages: 140
Weight: 0.43
Height: 0.33 Width: 6.00 Depth: 9.00
Language: Portuguese
As oscilações teta do hipocampo apoiam a codificação da posição de um animal durante a navegação espacial e a frequência teta está correlacionada com a velocidade de corrida. No entanto, se as oscilações teta do hipocampo regulam a locomoção permaneceu uma questão de longa data. Só recentemente é que vias cerebrais distintas podem ser manipuladas com alta precisão espacial e temporal usando optogenética. Neste estudo, as oscilações teta do hipocampo foram sincronizadas por excitação optogenética das células marcapasso do septo medial que se projetam para o hipocampo em frequências teta. A sincronização promoveu uma menor variabilidade da amplitude teta, o que mediou uma velocidade de corrida mais lenta e regular. A inibição farmacológica ou optogenética da principal saÃda subcortical do hipocampo, para o septo lateral, impediu o efeito comportamental da sincronização. Em conclusão, os resultados fornecem evidências de que as oscilações teta do hipocampo podem regular a velocidade locomotora através de uma via do septo lateral.
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