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Regulacja lokomocji przez oscylacje theta w hipokampie
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ISBN10: 6208983460
ISBN13: 9786208983468
Publisher: Wydawnictwo Nasza Wiedza
Published: Jun 20 2025
Pages: 140
Weight: 0.43
Height: 0.33 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786208983468
Publisher: Wydawnictwo Nasza Wiedza
Published: Jun 20 2025
Pages: 140
Weight: 0.43
Height: 0.33 Width: 6.00 Depth: 9.00
Language: Polish
Oscylacje theta w hipokampie wspomagają kodowanie pozycji zwierzęcia podczas nawigacji przestrzennej, a częstotliwośc theta jest skorelowana z prędkością biegu. Jednak kwestia, czy oscylacje theta w hipokampie regulują lokomocję, pozostawala od dawna otwarta. Dopiero od niedawna możliwe jest manipulowanie określonymi ścieżkami mózgowymi z dużą precyzją przestrzenną i czasową za pomocą optogenetyki. W niniejszym badaniu oscylacje theta w hipokampie zostaly zsynchronizowane poprzez optogenetyczne pobudzenie komórek rozrusznika przegrody środkowej, które wysylają impulsy do hipokampu z częstotliwością theta. Synchronizacja spowodowala zmniejszenie zmienności amplitudy theta, co spowodowalo spowolnienie i uregulowanie prędkości biegu. Farmakologiczne lub optogenetyczne zahamowanie glównego wyjścia podkorowego hipokampu do przegrody bocznej zapobieglo behawioralnemu efektowi synchronizacji. Podsumowując, wyniki badań dostarczają dowodów na to, że oscylacje theta w hipokampie mogą regulowac prędkośc lokomocji poprzez ścieżkę przegrody bocznej.
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