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Lipogenesi della parete arteriosa
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ISBN10: 6209546307
ISBN13: 9786209546303
Publisher: Edizioni Sapienza
Published: Jan 29 2026
Pages: 136
Weight: 0.42
Height: 0.32 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786209546303
Publisher: Edizioni Sapienza
Published: Jan 29 2026
Pages: 136
Weight: 0.42
Height: 0.32 Width: 6.00 Depth: 9.00
Language: Italian
LIPOGENESI DELLA PARETE ARTERIOSA: REGOLAZIONE DELLA SUA ESPRESSIONE E ANOMALIE NELL'INSULINO-RESISTENZA E NEL DIABETE Abbiamo studiato l'espressione e la regolazione della lipogenesi nell'aorta e nel CMLV e determinato se essa sia modificata dall'insulino-resistenza e dal diabete. I ratti Zucker obesi (ZO), diabetici e Psammomys obesus accumulano più lipidi nelle loro aorte rispetto ai controlli. Tuttavia, l'espressione dei geni della lipogenesi e di quelli coinvolti nell'assorbimento degli acidi grassi non è aumentata. Un risultato simile è stato riscontrato in campioni di endarterectomie umane. L'ambiente adipogenico, il glucosio o l'insulina da soli stimolano moderatamente la lipogenesi solo nei CML di controllo Zucker, mentre nessun effetto è stato osservato nei CML di ZO. Abbiamo dimostrato che gli effetti del TO901317 sulla lipogenesi nei CMLV sono dovuti esclusivamente all'attivazione del recettore nucleare LXRα, mentre il PXR non ha alcun effetto. In conclusione, la lipogenesi non è aumentata nella parete arteriosa durante l'insulino-resistenza e il diabete.
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