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Lipogeneza ściany tętnicy
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ISBN10: 6209536069
ISBN13: 9786209536069
Publisher: Wydawnictwo Nasza Wiedza
Published: Jan 29 2026
Pages: 132
Weight: 0.41
Height: 0.31 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786209536069
Publisher: Wydawnictwo Nasza Wiedza
Published: Jan 29 2026
Pages: 132
Weight: 0.41
Height: 0.31 Width: 6.00 Depth: 9.00
Language: Polish
LIPOGENEZA ŚCIANY TĘTNICZEGO: REGULACJA JEJ EKSPRESJI I ANOMALIE W INSULINO-REZYSTANCJI I CUKRZYCIE Zbadaliśmy ekspresję i regulację lipogenezy w aortach i CMLV oraz ustaliliśmy, czy jest ona modyfikowana przez insulino-rezystancję i cukrzycę. Otyle szczury Zucker (ZO), cukrzycowe i Psammomys obesus gromadzą więcej lipidów w aortach niż szczury kontrolne. Jednak ekspresja genów lipogenezy i genów zaangażowanych w wychwytywanie kwasów tluszczowych nie jest zwiększona. Podobny wynik uzyskano w próbkach pobranych podczas endarterektomii u ludzi. Środowisko adipogeniczne, glukoza lub sama insulina stymulują umiarkowanie lipogenezę wylącznie w komórkach CML kontrolnych szczurów rasy Zucker, nie zaobserwowano żadnego wplywu w komórkach CML szczurów ZO. Wykazaliśmy, że wplyw TO901317 na lipogenezę w CMLV wynika wylącznie z aktywacji receptora jądrowego LXRα, PXR nie ma żadnego wplywu. Podsumowując, lipogeneza nie jest zwiększona w ścianie tętnicy podczas insulinooporności i cukrzycy.
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