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Lipogénese da parede arterial
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ISBN10: 6209548865
ISBN13: 9786209548864
Publisher: Edicoes Nosso Conhecimento
Published: Jan 29 2026
Pages: 136
Weight: 0.42
Height: 0.32 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209548864
Publisher: Edicoes Nosso Conhecimento
Published: Jan 29 2026
Pages: 136
Weight: 0.42
Height: 0.32 Width: 6.00 Depth: 9.00
Language: Portuguese
LIPOGÊNESE DA PAREDE ARTERIAL: REGULAÇÃO DA SUA EXPRESSÃO E ANOMALIAS NA RESISTÊNCIA À INSULINA E NO DIABETES Estudamos a expressão e a regulação da lipogênese nas aortas e CMLV e determinamos se ela é alterada pela resistência à insulina e pelo diabetes. Os ratos Zucker obesos (ZO), diabéticos e Psammomys obesus acumulam mais lÃpidos nas aortas do que os seus controlos. No entanto, a expressão dos genes da lipogénese e dos genes envolvidos na captação de ácidos gordos não aumenta. Um resultado semelhante foi encontrado em amostras de endarterectomias em humanos. O meio adipogénico, a glicose ou a insulina isoladamente estimulam moderadamente a lipogénese apenas nas CML de Zucker de controlo, não tendo sido observado qualquer efeito nas CML de ZO. Demonstramos que os efeitos do TO901317 sobre a lipogénese nas CMLV se devem exclusivamente à ativação do recetor nuclear LXRα, o PXR não tem qualquer efeito. Em conclusão, a lipogénese não é aumentada na parede arterial durante a resistência à insulina e a diabetes.
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