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Proteina HSP70: potenziale marcatore diagnostico per l'infezione da W. bancrofti
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ISBN10: 6209208282
ISBN13: 9786209208287
Publisher: Edizioni Sapienza
Published: Nov 4 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786209208287
Publisher: Edizioni Sapienza
Published: Nov 4 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Italian
La filariosi linfatica (LF), una malattia parassitaria trasmessa dalle zanzare causata dalle specie Wuchereria bancrofti e Brugia, è una delle malattie tropicali più diffuse eppure più trascurate, con gravi conseguenze economiche e sociali. Poiché la fase microfilaremica asintomatica è considerata uno degli ostacoli principali all'eliminazione globale della LF, la ScHSP70 può essere un agente promettente per la diagnosi immunologica. Inoltre, a causa dell'indisponibilità di W. bancrofti e B. malayi, il parassita filariale bovino S. cervi può essere una buona fonte di antigeni eterologhi che possono essere esplorati come possibili candidati per la diagnosi, la chemioterapia e i vaccini. L'analisi proteomica è molto utile per caratterizzare ScHSP70 come proteina associata alla malattia, sebbene la proteomica sia stata eseguita su una piccola coorte. I risultati ottenuti in questo studio sono promettenti, ma sono necessari ulteriori studi sull'espressione ricombinante per determinarne l'accuratezza diagnostica nell'immunodiagnosi della filariosi linfatica in un'area endemica. Questo studio apre anche la possibilità di esplorare le proteine da shock termico per il loro utilizzo nella diagnosi di altre malattie da elminti.
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