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ProteÃna HSP70: potencial marcador diagnóstico para a infecção por W. bancrofti
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ISBN10: 6209213405
ISBN13: 9786209213403
Publisher: Edicoes Nosso Conhecimento
Published: Nov 4 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786209213403
Publisher: Edicoes Nosso Conhecimento
Published: Nov 4 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Portuguese
A filariose linfática (FL), uma doença parasitária transmitida por mosquitos causada pelas espécies Wuchereria bancrofti e Brugia, é uma das doenças tropicais mais prevalentes e, ainda assim, mais negligenciadas, com graves consequências económicas e sociais. Como a fase microfilariémica assintomática é considerada um dos obstáculos à eliminação global da FL, a ScHSP70 pode ser um agente promissor para o imunodiagnóstico. Além disso, devido à indisponibilidade de W. bancrofti e B. malayi, o parasita filarial bovino S. cervi pode ser uma boa fonte de antigénios heterólogos que podem ser explorados como possÃveis candidatos para diagnóstico, quimioterapia e vacinas. A análise proteómica é muito útil para caracterizar a ScHSP70 como uma proteÃna associada à doença, embora a proteómica tenha sido realizada numa pequena coorte. Os resultados obtidos neste estudo são promissores, mas são necessários mais estudos sobre a expressão recombinante para determinar a sua precisão diagnóstica no imunodiagnóstico da filariose linfática numa área endémica. Este estudo também abre a possibilidade de explorar as proteÃnas de choque térmico para o seu uso no diagnóstico de outras doenças helmÃnticas.
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