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Bialko HSP70: potencjalny marker diagnostyczny zakażenia W. bancrofti
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ISBN10: 6209210848
ISBN13: 9786209210846
Publisher: Wydawnictwo Nasza Wiedza
Published: Nov 4 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786209210846
Publisher: Wydawnictwo Nasza Wiedza
Published: Nov 4 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Polish
Filarioza limfatyczna (LF), choroba pasożytnicza przenoszona przez komary, wywolywana przez gatunki Wuchereria bancrofti i Brugia, jest jedną z najczęściej występujących, a jednocześnie najbardziej zaniedbanych chorób tropikalnych, mającą poważne konsekwencje gospodarcze i spoleczne. Ponieważ bezobjawowa faza mikrofilariozy jest uważana za jedną z przeszkód w globalnej eliminacji LF, ScHSP70 może byc obiecującym środkiem do diagnostyki immunologicznej. Ponadto, ze względu na niedostępnośc W. bancrofti i B. malayi, pasożyt filariowy bydla, S. cervi, może byc dobrym źródlem heterologicznych antygenów, które można zbadac jako potencjalne kandydaty do diagnostyki, chemioterapii i szczepionek. Analiza proteomiczna jest bardzo przydatna w charakteryzowaniu ScHSP70 jako bialka związanego z chorobą, chociaż proteomikę przeprowadzono w malej grupie. Wyniki uzyskane w tym badaniu są obiecujące, ale konieczne są dalsze badania nad ekspresją rekombinowaną w celu określenia jego dokladności diagnostycznej w immunodiagnostyce filariozy limfatycznej na obszarze endemicznym. Badanie to otwiera również możliwośc zbadania bialek szoku cieplnego pod kątem ich wykorzystania w diagnostyce innych chorób robaków pasożytniczych.
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