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Expressão do gene ATP6V1H na diabetes tipo 2
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ISBN10: 6139669642
ISBN13: 9786139669646
Publisher: Edicoes Nosso Conhecimento
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786139669646
Publisher: Edicoes Nosso Conhecimento
Published: Sep 17 2025
Pages: 68
Weight: 0.23
Height: 0.16 Width: 6.00 Depth: 9.00
Language: Portuguese
O objetivo desta pesquisa foi triplo: 1) estudar os parâmetros demográficos e fisiológicos de nove indivÃduos no CCHC que desenvolveram diabetes ao longo dos três anos do perÃodo do estudo; 2) investigar se o gene que codifica a subunidade H da V-ATPase (ATP6V1H) foi regulado negativamente nos nove indivÃduos à medida que progrediram da pré-diabetes para a diabetes tipo 2; 3) realizar uma extensa revisão da literatura sobre o gene ATP6V1H e o seu produto proteico, a subunidade H da V-ATPase, para postular qual o papel que poderia desempenhar no desenvolvimento da diabetes e das suas complicações. De acordo com a Organização Mundial da Saúde, existem aproximadamente 346 milhões de casos de diabetes em todo o mundo, 90% dos quais são atribuÃdos especificamente à diabetes tipo 2. À medida que a diabetes tipo 2 continua a suscitar preocupação, os investigadores começam a centrar a sua atenção nos fatores inerentes que predispõem os indivÃduos à doença, um dos quais é a genética. Recentemente, observou-se uma maior prevalência de diabetes tipo 2 numa coorte de 2500 membros de mexicano-americanos estabelecidos na fronteira entre os EUA e o México, especificamente em Brownsville (Condado de Cameron), Texas.
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