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Związek polimorfizmu pojedynczego nukleotydu genu TLR-2 i IL-33
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ISBN10: 6208820588
ISBN13: 9786208820589
Publisher: Wydawnictwo Nasza Wiedza
Published: Apr 2 2025
Pages: 128
Weight: 0.40
Height: 0.30 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786208820589
Publisher: Wydawnictwo Nasza Wiedza
Published: Apr 2 2025
Pages: 128
Weight: 0.40
Height: 0.30 Width: 6.00 Depth: 9.00
Language: Polish
Reumatoidalne zapalenie stawów (RZS) reprezentuje prototyp przewleklej choroby zapalnej; charakteryzuje się zapaleniem blony maziowej, zniszczeniem chrząstki, erozją kości, deformacją stawów i niepelnosprawnością funkcjonalną osoby dotkniętej chorobą. Przeprowadzono badanie molekularne i immunologiczne w celu określenia wplywu wariantów genetycznych genów IL-33 i TLR-2 na poziom IL-33 i TLR-2 u pacjentów z RZS, a także określono genotypy i allele związane z występowaniem choroby RZS.Studium przypadku obejmowalo 35 pacjentów z RZS cierpiących na zakażenie paciorkowcami pyogenes (4 mężczyzn i 31 kobiet) uczęszczających do ośrodka leczenia reumatoidalnego zapalenia stawów w Al-Sadder Medical City w prowincji AL-Najaf w okresie od listopada 2018 r. do końca stycznia 2019 r. Wiek badanych wynosil od 30 do 69 lat. Grupy kontrolne obejmowaly 15 zdrowych osób (5 mężczyzn i 10 kobiet) w tym samym wieku i tej samej plci co pacjenci, którzy zostali losowo wybrani ze szpitali i lokalnej spoleczności. Po zebraniu danych demograficznych i klinicznych od pacjentów, surowice wykorzystano do oznaczenia calkowitego poziomu IL-33, TLR-2 w surowicy za pomocą testu immunoenzymatycznego, testu anty-streptolizyny O (ASO).
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