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Associação do polimorfismo de nucleótido único do gene TLR-2 e IL-33
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ISBN10: 6208820596
ISBN13: 9786208820596
Publisher: Edicoes Nosso Conhecimento
Published: Apr 2 2025
Pages: 124
Weight: 0.39
Height: 0.29 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786208820596
Publisher: Edicoes Nosso Conhecimento
Published: Apr 2 2025
Pages: 124
Weight: 0.39
Height: 0.29 Width: 6.00 Depth: 9.00
Language: Portuguese
A artrite reumatoide (AR) representa o protótipo de doença inflamatória crónica, caracterizada por inflamação da membrana sinovial, destruição da cartilagem, erosão óssea, deformidade articular e incapacidade funcional do indivÃduo afetado. Foi realizado um estudo molecular e imunológico para determinar as influências das variantes genéticas dos genes IL-33 e TLR-2 no nÃvel de IL-33 e TLR-2 em doentes com AR, bem como para determinar os genótipos e alelos associados à incidência da doença de AR.O estudo de caso incluiu 35 pacientes com AR que sofrem de infeção por estreptococos pyogenes (4 homens e 31 mulheres) que frequentam o centro de doenças da artrite reumatoide em Al- Sadder Medical City em AL- Najaf Provenance no perÃodo que se estende de novembro de 2018 até o final de janeiro de 2019. As idades variaram de 30 a 69 anos. Os grupos de controle incluÃram 15 pessoas saudáveis (5 homens e 10 mulheres) com as mesmas idades e sexo dos pacientes foram selecionados aleatoriamente dos hospitais e da comunidade local. Depois de recolhidos os dados demográficos e clÃnicos dos doentes, os soros foram utilizados para determinar os nÃveis séricos totais de IL-33 e TLR-2 através do Enzyme-linked immunosorbent assay, Anti-streptolysinO(ASO)test
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