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Regolazione della locomozione mediante oscillazioni theta dell'ippocampo
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ISBN10: 6208983509
ISBN13: 9786208983505
Publisher: Edizioni Sapienza
Published: Jun 20 2025
Pages: 144
Weight: 0.44
Height: 0.34 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786208983505
Publisher: Edizioni Sapienza
Published: Jun 20 2025
Pages: 144
Weight: 0.44
Height: 0.34 Width: 6.00 Depth: 9.00
Language: Italian
Le oscillazioni theta dell'ippocampo supportano la codifica della posizione di un animale durante la navigazione spaziale e la frequenza theta è correlata alla velocità di corsa. Tuttavia, se le oscillazioni theta dell'ippocampo regolino la locomozione è rimasta una questione aperta per molto tempo. Solo di recente è diventato possibile manipolare distinti percorsi cerebrali con elevata precisione spaziale e temporale utilizzando l'optogenetica. In questo studio, le oscillazioni theta dell'ippocampo sono state entrainate eccitando optogeneticamente le cellule pacemaker del setto mediale che si proiettano verso l'ippocampo a frequenze theta. L'entrainment ha favorito una minore variabilità dell'ampiezza theta, che ha mediato una velocità di corsa più lenta e regolare. L'inibizione farmacologica o optogenetica dell'output subcorticale principale dell'ippocampo, verso il setto laterale, ha impedito l'effetto comportamentale dell'entrainment. In conclusione, i risultati dimostrano che le oscillazioni theta dell'ippocampo possono regolare la velocità locomotoria attraverso una via del setto laterale.
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