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Bakterientherapie bei allergischen Erkrankungen
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ISBN10: 620893138X
ISBN13: 9786208931384
Publisher: Verlag Unser Wissen
Published: Jun 17 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: German
ISBN13: 9786208931384
Publisher: Verlag Unser Wissen
Published: Jun 17 2025
Pages: 84
Weight: 0.27
Height: 0.20 Width: 6.00 Depth: 9.00
Language: German
Jüngste epidemiologische Studien und klinische Versuche deuten auf eine mögliche Rolle bestimmter Milchsäurebakterienstämme (LAB) bei der Vorbeugung von allergischen Erkrankungen hin. In dieser Studie haben wir das immunmodulatorische Potenzial von zwei LAB-Stämmen, Lactococcuslactis und Lactobacillus plantarum, für die Prophylaxe und Therapie von allergischen Immunreaktionen untersucht. Beide LAB-Stämme - induzierten in naiven Milzzellkulturen von Mäusen hohe Mengen an IL-12 und IFN. Die gleichzeitige intranasale Verabreichung von rekombinantem Bet v 1, dem Hauptallergen der Birkenpollen, vor oder nach einer allergischen Sensibilisierung führte zu einer Erhöhung der allergenspezifischen IgG2a-Antikörper und der In-vitro-IFN-Produktion, was auf eine Verschiebung hin zu Th1-Reaktionen hinweist. Die erfolgreiche Immunmodulation durch die mukosale Vorbehandlung wurde au erdem durch die Unterdrückung der Allergen-induzierten basophilen Degranulation nachgewiesen. Wir kommen zu dem Schluss, dass diese LAB-Stämme in Kombination mit einem Allergen vielversprechende Kandidaten für eine mukosale Impfung gegen Typ-I-Allergien sein könnten.
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